By Loder, Bunt, Wyatt. Abstract The way we create, access and share information is changing rapidly. Every time we look something up on Wikipedia, rate…
By Michie, S., et al. Abstract CONSORT guidelines call for precise reporting of behavior change interventions: we need rigorous methods of characterizing active content of…
By McMurry AJ, Murphy SN, MacFadden D, Weber G, Simons WW, et al. Abstract Results of medical research studies are often contradictory or cannot be…
By Ruth R. Faden, Nancy E. Kass, Steven N. Goodman, Peter Pronovost, Sean Tunis, and Tom L. Beauchamp. Abstract Calls are increasing for American health…
By Solomon, M. Z. and Bonham, A. C. Abstract The Institute of Medicine has called on health care leaders to transform their health systems into…
By Kass, N. E., Faden, R. R., Goodman, S. N., Pronovost, P., Tunis, S. and Beauchamp, T. L. Abstract The rise of quality improvement research…
By Greene SM, Reid RJ, Larson EB. Clinicians and health systems are facing widespread challenges, including changes in care delivery, escalating health care costs, and…
By Kenneth D Mandl , Joshua C Mandel , Shawn N Murphy, et al. AbstractObjective: The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks…
By Charles Friedman, Michael Rigby. Abstract In any country the health sector is important in terms of human wellbeing and large in terms of economics.…
By Yu, M., Xie, D., Wang, X., Weiner, M. G. and Tannen, R. L. ABSTRACTPurposeThe purpose of this study was to evaluate a statistical method,…
By Berger, M. L., et al. Abstract OBJECTIVE: In both the United States and Europe there has been an increased interest in using comparative effectiveness…
By Greenfield, S. and R. Platt Abstract “It is the position of this Task Force that rigorous well designed and well executed Observational Studies (OS)…
By Delaney B, Peterson K A., Speedie S, Taweel A, Arvanitis T, Hobbs R. Abstract PURPOSE: The learning health care system refers to the cycle…
By Harcourt, S. E., et al. Abstract The Health Protection Agency/QSurveillance national surveillance system utilizes QSurveillance®, a recently developed general practitioner database covering over 23…
By Jennifer Frankovich, M.D., Christopher A. Longhurst, M.D., and Scott M. Sutherland, M.D. Abstract Pediatricians facing critical clinical decisions often lack data on which to draw.…
By Michie, S., et al. Abstract Background Improving the design and implementation of evidence-based practice depends on successful behaviour change interventions. This requires an appropriate…
By Appleby, et al. Variations in health care in the NHS are a persistent and ubiquitous problem. But which variations are acceptable or warranted –…
By Charles P. Friedman, Adam K. Wong and David Blumenthal Abstract We outline the fundamental properties of a highly participatory rapid learning system that…
By C. P. Friedman, A. K. Wong, D. Blumenthal. Abstract We outline the fundamental properties of a highly participatory rapid learning system that can…
By Brown, J. et al. Abstract BACKGROUND: Comparative effectiveness research, medical product safety evaluation, and quality measurement will require the ability to use electronic health…
By Lewis, G. H. Abstract Context: Predictive models can be used to identify people at high risk of unplanned hospitalization, although some of the high-risk…
By Institure of Medicine. Abstract The United States has the highest per capita spending on health care of any industrialized nation. Yet despite the unprecedented…
By Bradley, E. H., et al. BackgroundDespite decades of efforts to improve quality of health care, poor performance persists in many aspects of care. Less…
By Tannen Richard L, Weiner Mark G, Xie Dawei. Abstract Objectives To determine whether observational studies that use an electronic medical record database can provide…
By Miller, F. G. Abstract Observational research involving access to personally identifiable data in medical records has often been conducted without informed consent, owing to…
By Sanson-Fisher, R. W., et al. Abstract Population- and systems-based interventions need evaluation, but the randomized controlled trial (RCT) research design has significant limitations when…
By Lynn M. Etheredge. Abstract Private- and public-sector initiatives, using electronic health record (EHR) databases from millions of people, could rapidly advance the U.S. evidence…
By Johnston, S. C., et al. Abstract BACKGROUND: Few attempts have been made to estimate the public return on investment in medical research. The total…
By Kawamoto, K., et al. Abstract Objective To identify features of clinical decision support systems critical for improving clinical practice. Design Systematic review of randomised…
By Rothwell, P. M. Abstract In making treatment decisions, doctors and patients must take into account relevant randomised controlled trials (RCTs) and systematic reviews. Relevance…
By Matzen P. INTRODUCTION: In the early 1990es, it was supposed that only 10-15 per cent of medical interventions were based on results from randomised…
By Mann, C. J. Abstract Cohort, cross sectional, and case-control studies are collectively referred to as observational studies. Often these studies are the only practicable…
By Helms, P. J. Abstract Although the explanatory clinical therapeutic trial remains the foundation for assessing drug efficacy and is required for licensing purposes, the…
By Sibbald, B. and M. Roland. Abstract Randomised controlled trials are the most rigorous way of determining whether a cause-effect relation exists between treatment and…
By Black, N. Abstract The view is widely held that experimental methods (randomised controlled trials) are the “gold standard” for evaluation and that observational methods…
By Sackett, et al. Abstract It's about integrating individual clinical expertise and the best external evidence Evidence based medicine, whose philosophical origins extend back to…
By Davidoff, Frank et al. Abstract A new journal to help doctors identify the information they need Busy doctors have never had time to read…