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References Report 2021

[1]        T. Foley and F. Fairmichael, “The Potential of Learning Health Care Systems,” The Learning Healthcare Project, 2015. [Online]. Available: https://learninghealthcareproject.org/the-potential-of-learning-healthcare-systems/

[2]        C. P. Friedman et al., “The science of learning health systems: foundations for a new journal,” Learning Health Systems, vol. 1, no. 1, 2017. [Online]. Available: https://onlinelibrary.wiley.com/doi/full/10.1002/lrh2.10020.

[3]        D. A. Garwin. (1993) Building a Learning Organization. Harvard Business Review. 73-91. Available: https://hbr.org/1993/07/building-a-learning-organization

[4]        J. M. McGinnis, D. Aisner, and L. O. Olsen, “The Learning Healthcare System,” National Academies Press, Washington (DC), USA, 2007. [Online]. Available: https://www.nap.edu/catalog/11903/the-learning-healthcare-system-workshop-summary

[5]        J. M. McGinnis, L. Stuckhardt, R. Saunders, and M. Smith, Best care at lower cost: the path to continuously learning health care in America. National Academies Press, 2013.

[6]        J. Enticott, A. Johnson, and H. Teede, “Learning health systems using data to drive healthcare improvement and impact: a systematic review,” BMC health services research, vol. 21, no. 1, pp. 1-16, 2021. [Online]. Available: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-021-06215-8#Tab3.

[7]        T. Foley and F. Fairmichael. “Professor Charles Friedman Interview.” The Learning Healthcare Project. https://www.learninghealthcareproject.org/section/evidence/25/50/professor-charles-friedman-%20interview

[8]        University of Michigan. “Revolutionizing Learning, Transforming Health.” University of Michigan. https://medicine.umich.edu/dept/learning-health-sciences

[9]        MCBK. “Annual MCBK Public Meeting.” MCBK. https://mobilizecbk.med.umich.edu/news-events/annual-meetings

[10]      MCBK. “Featured Events.” Mobilizing Computable Biomedical Knowledge (MCBK). https://mobilizecbk.med.umich.edu/news-events

[11]      C. Friedman. “Learning Health Systems.” https://onlinelibrary.wiley.com/journal/23796146

[12]      T. Foley. “LHS Value.” The Learning Healthcare Project. https://www.learninghealthcareproject.org/section/implications/value

[13]      T. Foley. “Positive Deviance.” The Learning Healthcare Project. https://www.learninghealthcareproject.org/section/use-cases/positive-deviance

[14]      T. Foley. “Comparative Effectiveness Research.” The Learning Healthcare Project. https://www.learninghealthcareproject.org/section/use-cases/comparative-effectiveness-research

[15]      T. Foley. “Surveillance.” The Learning Healthcare Project. https://www.learninghealthcareproject.org/section/use-cases/surveillance

[16]      T. Shaw et al., “Attitudes of health professionals to using routinely collected clinical data for performance feedback and personalised professional development,” Medical Journal of Australia, vol. 210, no. S6, pp. S17-S21, 2019, doi: https://doi.org/10.5694/mja2.50022.

[17]      M. M. Helms and J. Nixon, “Exploring SWOT analysis–where are we now? A review of academic research from the last decade,” Journal of Strategy and Management, vol. 3, no. 3, pp. 215–251, 2010. [Online]. Available: https://www.emerald.com/insight/content/doi/10.1108/17554251011064837/full/html.

[18]      (2020). The green book: Central government guidance on appraisal and evaluation. [Online] Available: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/938046/The_Green_Book_2020.pdf

[19]      Y. Zurynski et al., “Mapping the learning health system: A scoping review of current evidence,” Australian Institute of Health Innovation, Sydney, Australia, 2020. [Online]. Available: https://research-management.mq.edu.au/ws/portalfiles/portal/134364432/Publisher_version_open_access_.pdf

[20]      HDR UK. “Better Care.” Health Data Research UK (HDRUK). https://www.hdruk.ac.uk/how-we-use-health-data/better-care/ (accessed.

[21]      J. Farenden and I. Singh, “Local Health and Care Record Exemplars: A summary,” NHS England, 2018. [Online]. Available: https://www.england.nhs.uk/wp-content/uploads/2018/05/local-health-and-care-record-exemplars-summary.pdf

[22]      Learning Health System for CYP. “Learning Health System for CYP.” Children and Young People’s Health Partnership. https://www.cyphp.org/cyp-professionals/model-of-care/learning-health-system-for-cyp (accessed.

[23]      T. Foley and F. Fairmichael. “Geisinger Health System Site Visit.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/section/evidence/34/63/site-visit-to-geisinger-health-system (accessed.

[24]      S. Abimbola et al., “The NASSS framework for ex post theorisation of technology-supported change in healthcare: worked example of the TORPEDO programme,” BMC medicine, vol. 17, no. 1, pp. 1-17, 2019. [Online]. Available: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1463-x.

[25]      ImproveCareNow. “ImproveCareNow ” https://www.improvecarenow.org/ (accessed.

[26]      Mayo Clinic. “Platform revolution: Curing more people, reaching more lives, anytime, anywhere.” Mayo Clinic. https://newsnetwork.mayoclinic.org/discussion/platform-revolution-curing-more-people-reaching-more-lives-anytime-anywhere/ (accessed.

[27]      MCBK. “Mobilizing Computable Biomedical Knowledge community ” https://mobilizecbk.med.umich.edu/ (accessed.

[28]      R. Bohmer, J. Shand, D. Allwood, A. Wragg, and J. Mountford. “Learning Systems: Managing Uncertainty in the New Normal of Covid-19.” NEJM Catalyst Innovations in Care delivery. https://catalyst.nejm.org/doi/pdf/10.1056/CAT.20.0318 (accessed.

[29]      Open Lab. “About Open Lab ” https://openlab.ncl.ac.uk/ (accessed.

[30]      L. I. Horwitz, M. Kuznetsova, and S. A. Jones, “Creating a Learning Health System through Rapid-Cycle, Randomized Testing,” The new england journal of medicine, vol. 381, no. 12, pp. 1175-1179, 2019. [Online]. Available: http://sumry.s3.amazonaws.com/uc/a5d6aec2707df51d9ba9c671a1610f05_SoundingboardNEJM.pdf.

[31]      NICE. “NICE Connect.” The National Institute for Health and Care Excellence (NICE) https://www.nice.org.uk/about/who-we-are/nice-connect (accessed.

[32]      NHS Digital. “Improving our Data Processing.” NHS Digital. https://digital.nhs.uk/data-and-information/data-insights-and-statistics/improving-our-data-processing-services (accessed 2021).

[33]      OpenClinical. “OpenClinical.” OpenClinical. http://www.openclinical.net (accessed.

[34]      PatientsLikeMe. “About PatientsLikeME.” https://www.patientslikeme.com/ (accessed.

[35]      A. Wales, “Decision support for Scotland’s health and social care: learning from an outcomes-focused approach,” BMJ Health & Care Informatics, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100124

[36]      Medics Academy. “Ann Wales Presentation – UK Workshop on Mobilising Computable Biomedical Knowledge (MCBK).” Medics Academy. https://www.youtube.com/watch?v=vWEKM2UYBzg (accessed.

[37]      N. Mastellos et al., “Feasibility and acceptability of TRANSFoRm to improve clinical trial recruitment in primary care,” Family Practice, vol. 33, no. 2, pp. 186–191, 2016. [Online]. Available: https://academic.oup.com/fampra/article/33/2/186/2404251?login=true.

[38]      A. J. Flynn, C. P. Friedman, P. Boisvert, Z. Landis‐Lewis, and C. Lagoze, “The Knowledge Object Reference Ontology (KORO): A formalism to support management and sharing of computable biomedical knowledge for learning health systems,” Wiley Online Library, 2018. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/31245583/

[39]      G. Bellinger, D. Castro, and A. Mills. “Systems Thinking.” https://www.systems-thinking.org/dikw/dikw.htm (accessed.

[40]      T. Foley and F. Fairmichael. “Dr Paul Wallace Interview.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/section/evidence/24/66/dr-paul-wallace-interview (accessed.

[41]      T. Foley. “Platforms in LHS Workshop.” The Learning Healthcare Project. www.learninghealthcareproject.org (accessed.

[42]      M. Inada-Kim and T. Donnelly. “Tech supported remote monitoring for COVID-19.” NHS England. https://www.nhsx.nhs.uk/blogs/tech-supported-remote-monitoring-covid-19/ (accessed.

[43]      J. Z. Muller, The tyranny of metrics. New Jersey, USA: Princeton University Press, 2018.

[44]      V. d. Merwe et al., “Making sense of complexity: Using sensemaker as a research tool,” MDPI, vol. 7, no. 2, p. 25, 2019. [Online]. Available: https://www.mdpi.com/2079-8954/7/2/25.

[45]      S. Xu, T. Rogers, E. Fairweather, A. Glenn, J. Curran, and V. Curcin, “Application of Data Provenance in Healthcare Analytics Software: Information Visualisation of User Activities,” AMIA Summits on Translational Science Proceedings, pp. 263–272, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961786/.

[46]      NHS Digital. “Data, insights, and statistics.” NHS Digital. https://digital.nhs.uk/data-and-information/data-insights-and-statistics (accessed.

[47]      J. S. Brown, J. H. Holmes, K. Shah, K. Hall, R. Lazarus, and R. Platt, “Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care,” Medical Care, pp. 45-51, 2010. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/20473204/.

[48]      Sentinel System. “Sentinel System.” https://www.sentinelinitiative.org/about/how-sentinel-gets-its-data (accessed 2021).

[49]      T. Foley and F. Fairmichael. “Dr Jeff Brown Interview.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/publication/5/60/dr-jeff-brown-interview (accessed.

[50]      NHS Digital. “Data Access Environment (DAE).” NHS Digital. https://digital.nhs.uk/services/data-access-environment-dae (accessed.

[51]      NHSX. “Information governance (IG).” NHSX. https://www.nhsx.nhs.uk/information-governance/ (accessed.

[52]      UK Gov. “Data Protection Act ” UK Public General Acts. https://www.legislation.gov.uk/ukpga/1998/29 (accessed.

[53]      ICO. “Data protection and coronavirus information hub.” Information Commissioners Office. https://ico.org.uk/ (accessed.

[54]      CDC. “Health Information Privacy.” Center for Disease Control. https://www.cdc.gov/phlp/publications/topic/healthinformationprivacy.html (accessed.

[55]      D. B. Rubin, “On the limitations of comparative effectiveness research,” Statistics in Medicine, vol. 29, no. 19, pp. 1991-1995, 2010. [Online]. Available: https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.3960.

[56]      ONC, “Connecting Health and Care for the Nation: A 10-Year Vision to Achieve an Interoperable Health IT Infrastructure,” The Office of the National Coordinator for Health Information Technolody, 2014. [Online]. Available: https://www.healthit.gov/sites/default/files/ONC10yearInteroperabilityConceptPaper.pdf

[57]      N. Sebire, C. Cake, and A. Morris, “HDR UK supporting mobilising computable biomedical knowledge in the UK,” BMJ Health & Care Informatics, vol. 27, no. 2, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100122.

[58]      T. Foley and F. Fairmichael. “IBM Site Visit.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/publication/6/84/ibm-watson-site-visit (accessed.

[59]      T. Foley and F. Fairmichael. “Improving the Underlying Data Focus Group.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/section/evidence/12/69/improving-the-underlying-data-focus- (accessed.

[60]      NHS Digital. “Data Standards Team.” NHS Digital. https://digital.nhs.uk/data-and-information/data-insights-and-statistics/data-standards-team (accessed.

[61]      NHS Digital. “SNOMED CT.” NHS Digital. https://digital.nhs.uk/services/terminology-and-classifications/snomed-ct (accessed.

[62]      NHS Business Services Authority. “Dictionary of medicines and devices (dm+d).” NHS Business Services Authority. https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliance-contractors/dictionary-medicines-and-devices-dmd (accessed.

[63]      NHS. “NHS Classifications ICD-10.” NHS Digital. https://isd.digital.nhs.uk/trud3/user/guest/group/0/pack/28 (accessed.

[64]      NHS. “NHS Classifications ICD-10 and OPCS-4 eVersion.” NHS Digital. https://isd.digital.nhs.uk/trud3/user/guest/group/0/pack/37 (accessed.

[65]      NHS Digital. “Data Provision Notices (DPNs).” NHS Digital. https://digital.nhs.uk/about-nhs-digital/corporate-information-and-documents/directions-and-data-provision-notices/data-provision-notices-dpns (accessed.

[66]      T. Foley. “Mr Kingsley Manning Interview.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/publication/5/103/mr-kingsley-manning-interview (accessed.

[67]      Health IT. “ONC’s Cures Act Final Rule.” Health IT. https://www.healthit.gov/curesrule/ (accessed.

[68]      C. Jason. (2020) Epic Leads Almost 60 Health Systems Against Interoperability Rule. EHR Intelligence. Available: https://ehrintelligence.com/news/epic-leads-almost-60-health-systems-against-interoperability-rule

[69]      M. Savage, A. Neinstein, and J. Adler-Milstein. (2020) Measure The Impact Of The ONC’s New Interoperability Rules Now. Health Affairs. Available: https://www.healthaffairs.org/do/10.1377/hblog20200701.58142/full/

[70]      R. F. Gunst and R. L. Mason, “Fractional factorial design,” Wiley Interdisciplinary Reviews: Computational Statistics, vol. 1, no. 2, pp. 234-244, 2009. [Online]. Available: https://onlinelibrary.wiley.com/doi/abs/10.1002/wics.27.

[71]      P. Pallmann et al., “Adaptive designs in clinical trials: why use them, and how to run and report them,” BMC medicine, vol. 16, no. 1, pp. 1-15, 2018. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/29490655/.

[72]      S. Ellenberg, “The Stepped-Wedge Clinical Trial: Evaluation by Rolling Deployment,” Jama, vol. 319, no. 6, pp. 607-608, 2018. [Online]. Available: https://jamanetwork.com/journals/jama/article-abstract/2672617.

[73]      R. B. Penfold and F. Zhang, “Use of interrupted time series analysis in evaluating health care quality improvements,” Academic pediatrics, vol. 13, no. 6, pp. S38-S44, 2013. [Online]. Available: https://www.sciencedirect.com/science/article/abs/pii/S1876285913002106.

[74]      S. Devkaran and P. N. O’Farrell, “The impact of hospital accreditation on quality measures: an interrupted time series analysis.,” BMC health services research, vol. 15, no. 1, 2015. [Online]. Available: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-015-0784-5.

[75]      S. Desai and J. M. McWilliams, “Consequences of the 340B drug pricing program,” New England Journal of Medicine, vol. 378, no. 6, pp. 539-548, 2018. [Online]. Available: https://www.nejm.org/doi/full/10.1056/nejmsa1706475.

[76]      L. Bernal, J. S. Cummins, and A. Gasparrini, “The use of controls in interrupted time series studies of public health interventions.” International journal of epidemiology,” International journal of epidemiology, vol. 47, no. 6, pp. 2082-2093, 2018. [Online]. Available: https://academic.oup.com/ije/article/47/6/2082/5049576?login=true.

[77]      M. ML and B. A., “Regression Discontinuity Design,” JAMA, no. 4, pp. 381-382., 2020. [Online]. Available: https://jamanetwork.com/journals/jama/article-abstract/2768094.

[78]      T. N. Beran and C. Violato, “Structural equation modeling in medical research: a primer,” BMC research notes, vol. 3, no. 1, pp. 1-10, 2010. [Online]. Available: https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-3-267.

[79]      P. O. Owili, M. A. Muga, B. R. Mendez, and B. Chen, “Quality of maternity care and its determinants along the continuum in Kenya: A structural equation modeling analysis,” PloS one, vol. 12, no. 5, p. e0177756, 2017. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/28520771/.

[80]      J. D. Angrist, G. W. Imbens, and D. B. Rubin, “Identification of causal effects using instrumental variables,” Journal of the American statistical Association, vol. 91, no. 434, pp. 444-455, 1996. [Online]. Available: https://www.tandfonline.com/doi/abs/10.1080/01621459.1996.10476902?src=recsys.

[81]      S. M. Iacus, G. King, and G. Porro, “Causal inference without balance checking: Coarsened exact matching,” Political analysis, pp. 1-24, 2012. [Online]. Available: https://www.jstor.org/stable/41403736.

[82]      A. Pfadt and D. J. Wheeler, “Using statistical process control to make data-based clinical decisions. ,” Journal of applied behavior analysis, vol. 28, no. 3, pp. 349-370, 1995. [Online]. Available: https://onlinelibrary.wiley.com/doi/10.1901/jaba.1995.28-349.

[83]      B. E. Bejnordi et al., “Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer,” Jama, vol. 318, no. 22, pp. 2199-2210, 2017. [Online]. Available: https://jamanetwork.com/journals/jama/fullarticle/2665774.

[84]      C. W. Seymour et al., “Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. ,” Jama, vol. 321, no. 20, pp. 2003-2017, 2019. [Online]. Available: https://jamanetwork.com/journals/jama/article-abstract/2733996.

[85]      M. Pavlou, Ambler, S. G., S.R., O. Guttmann, P. Elliott, M. King, and R. Z. Omar, “How to develop a more accurate risk prediction model when there are few events,” Bmj, no. 351, p. p.h3868., 2015. [Online]. Available: https://www.bmj.com/content/351/bmj.h3868.full.

[86]      R. Miotto, B. A. K. Li Li, and J. T. Dudley, “Deep patient: an unsupervised representation to predict the future of patients from the electronic health records,” Scientific reports, vol. 6, no. 1, pp. 1-10, 2016. [Online]. Available: https://www.nature.com/articles/srep26094.

[87]      G. Liang, W. Fan, H. Luo, and X. Zhu, “The emerging roles of artificial intelligence in cancer drug development and precision therapy ” Biomedicine & Pharmacotherapy, no. 128, p. 110255, 2020. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0753332220304479.

[88]      A. Z. Woldaregay et al., “Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in type 1 diabetes. ,” Artificial intelligence in medicine, no. 98, pp. 109-134, 2019. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0933365717306218.

[89]      C. A. Longhurst, R. A. Harrington, and N. H. Shah, “A ‘green button’for using aggregate patient data at the point of care,” Health affairs, vol. 33, no. 7, pp. 1229-1235, 2014. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/25006150/.

[90]      GL Shostack, “Designing Services that Deliver,” Harvard Business Review, 1984. [Online]. Available: https://hbr.org/1984/01/designing-services-that-deliver.

[91]      L. K. Hall, B. F. Kunz, E. V. Davis, R. I. Dawson, and R. S. Power, “The cancer experience map: an approach to including the patient voice in supportive care solutions,” Journal of medical Internet research, vol. 17, no. 5, 2015. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468569/.

[92]      M. Rother and J. Shook, “Learning to See: value-stream mapping to create value and eliminate muda,” Brookline, Massachusetts: Lean Enterprise Institute, 2009. [Online]. Available: https://www.lean.org/Bookstore/ProductDetails.cfm?SelectedProductId=9.

[93]      E. H. Bradley, L. A. Curry, and K. J. Devers, “Qualitative data analysis for health services research: developing taxonomy, themes, and theory,” Health services research, vol. 42, no. 4, pp. 1758-1772, 2007. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/17286625/.

[94]      L. Wilson and T. Lowe, The Learning Communities: Collective Improvement in Complex Environments. Newcastle Upon Tyne, UK: Newcastle University, 2019.

[95]      L. Ferguson, M. Dibble, M. Williams, and J. Ferraro, “Operationalizing a learning community for a learning health system: a practical guide,” 2020. [Online]. Available: https://deepblue.lib.umich.edu/bitstream/handle/2027.42/163515/LearningCommunityPracticalGuide_FINAL.pdf?sequence=1&isAllowed=y

[96]      F. o. C. Informatics. “Nick Booth Introduction- UK Workshop on Mobilising Computable Biomedical Knowledge (MCBK).” Faculty of Clinical Informatics. https://www.youtube.com/playlist?list=PLn7CfTWFFBSzTZtK4bTpo7Q2kBLjr0RUM (accessed.

[97]      J. Wyatt and P. Scott, “Computable knowledge is the enemy of disease ” BMJ Health Care Informatics, vol. 27, no. 2, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100200.

[98]      K. Walsh and C. Wroe, “Mobilising computable biomedical knowledge: challenges for clinical decision support from a medical knowledge provider,” BMJ Health Care Informatics, vol. 27, no. 2, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100121.

[99]      D. Wong and N. Peek, “Does not compute: challenges and solutions in managing computable biomedical knowledge,” BMJ Health Care Informatics, vol. 27, no. 2, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100123.

[100]    Faculty of Clinical Informatics. “David Wong Talk – UK Workshop on Mobilising Computable Biomedical Knowledge (MCBK).” Mobilising Computable Biomedical Knowledge (MCBK). https://www.youtube.com/watch?v=AZCl7xzXkKU&list=PLn7CfTWFFBSzTZtK4bTpo7Q2kBLjr0RUM&index=9 (accessed.

[101]    K. D. Mandl and I. S. Kohane, “No Small Change for the Health Information Economy,” The New England Journal of Medicine, vol. 360, pp. 1278-1281, 2009. [Online]. Available: https://europepmc.org/article/med/19321867.

[102]    L. Ohno-Machado et al., “The guideline interchange format: a model for representing guidelines,” Journal of the American Medical Informatics Association, vol. 5, no. 4, pp. 357-372., 1998. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/9670133/.

[103]    HL7 & Boston Children’s Hospital. “Home Page – CDS Hooks.” HL7 & Boston Children’s Hospital. https://cds-hooks.org/ (accessed.

[104]    OpenEHR Foundation. “OpenEHR.” openEHR Foundation. https://www.openehr.org/ (accessed.

[105]    NHS Digital. “DCB0129.” https://digital.nhs.uk/data-and-information/information-standards/information-standards-and-data-collections-including-extractions/publications-and-notifications/standards-and-collections/dcb0129-clinical-risk-management-its-application-in-the-manufacture-of-health-it-systems (accessed.

[106]    NHS Digital. “DCP0160.” NHS Digital. https://digital.nhs.uk/data-and-information/information-standards/information-standards-and-data-collections-including-extractions/publications-and-notifications/standards-and-collections/dcb0160-clinical-risk-management-its-application-in-the-deployment-and-use-of-health-it-systems (accessed.

[107]    UK Gov. “Health and Social Care Act.” Legislation UK. https://www.legislation.gov.uk/ukpga/2012/7/contents/enacted (accessed.

[108]    UK Gov. “Guidance Notified bodies for medical devices.” Gov UK. https://www.gov.uk/government/publications/notified-bodies-for-medical-devices/notified-bodies-for-medical-devices (accessed.

[109]    UK Gov. “Approved bodies for medical devices.” https://www.gov.uk/government/publications/approved-bodies-for-medical-devices (accessed.

[110]    M. D. Wilkinson et al., “The FAIR Guiding Principles for scientific data management and stewardship,” Scientific data, vol. 3, no. 1, pp. 1-9, 2016. [Online]. Available: https://www.nature.com/articles/sdata201618.

[111]    G. Iacobucci, “Computer error may have led to incorrect prescribing of statins to thousands of patients,” The BMJ, 2016. [Online]. Available: https://www.bmj.com/content/353/bmj.i2742.

[112]    Digital Health. “QRisk2 in TPP “fixed” but up to 270,000 patients affected.” Digital Health. https://www.digitalhealth.net/2016/06/qrisk2-in-tpp-fixed-but-up-to-270000-patients-affected/ (accessed.

[113]    L. McIntosh and C. Shaffer. “Technical Infrastructure.” Mobilising Computable Biomedical Knowledge (MCBK). https://mobilizecbk.med.umich.edu/workgroups/technical-infrastructure (accessed.

[114]    C. P. Friedman and A. J. Flynn, “Computable knowledge: An imperative for Learning Health Systems,” Learning Health Systems, vol. 3, no. 4, 2019. [Online]. Available: https://onlinelibrary.wiley.com/doi/full/10.1002/lrh2.10203.

[115]    J. Swan et al., “Evidence in Management Decisions (EMD): advancing knowledge utilization in healthcare management,” 2012. [Online]. Available: https://www.bl.uk/collection-items/evidence-in-management-decisions-emd-advancing-knowledge-utilization-in-healthcare-management-executive-summary#.

[116]    T. Foley. “Professor Brendan Delaney Interview.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/publication/5/104/the-transform-project (accessed.

[117]    A. Hern. “Royal Free breached UK data law in 1.6m patient deal with Google’s DeepMind This article is more than 3 yea.” The Guardian. https://www.theguardian.com/technology/2017/jul/03/google-deepmind-16m-patient-royal-free-deal-data-protection-act (accessed.

[118]    J. A. Bernstein, C. Friedman, P. Jacobson, and J. C. Rubin, “Ensuring public health’s future in a national-scale learning health system,” American Journal of Preventive Medicine, vol. 48, no. 4, pp. 480-487, 2015. [Online]. Available: https://www.sciencedirect.com/science/article/abs/pii/S0749379714006710.

[119]    C. P. Friedman, A. K. Wong, and D. Blumenthal, “Achieving a nationwide learning health system,” Science translational medicine, vol. 2, no. 57, pp. 29-57, 2010. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/21068440/.

[120]    National Academy of Medicine. “The Learning Health System Series.” National Academy of Medicine. https://nam.edu/programs/value-science-driven-health-care/learning-health-system-series/ (accessed.

[121]    J. Braithwaite, K. C. J. C. Long, L. A. Ellis, and J. Herkes, “When complexity science meets implementation science: a theoretical and empirical analysis of systems change ” BMC medicine, vol. 16, no. 1, p. 63, 2018. [Online]. Available: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1057-z.

[122]    J. Braithwaite, P. Glasziou, and J. Westbrook, “The three numbers you need to know about healthcare: the 60-30-10 Challenge,” BMC medicine, vol. 18, pp. 1-8, 2020. [Online]. Available: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01563-4.

[123]    J. Braithwaite, “Changing how we think about healthcare improvement,” BMJ, vol. 361, 2018. [Online]. Available: https://www.bmj.com/content/361/bmj.k2014.

[124]    D. J. Snowden and M. E. Boone. “A Leader’s Framework for Decision Making.” Harvard Business Review. https://hbr.org/2007/11/a-leaders-framework-for-decision-making (accessed.

[125]    D. Snowden, “The Cynefin framework,” YouTube video, vol. 8, p. 38, 2010. [Online]. Available: https://www.youtube.com/watch?v=N7oz366X0-8.

[126]    D. Snowden. “7 principles of intervention in complex systems.” Cognitive Edge. https://www.cognitive-edge.com/7-principles-of-intervention-in-complex-systems/ (accessed.

[127]    T. Greenhalgh et al., “Beyond adoption: a new framework for theorizing and evaluating nonadoption, abandonment, and challenges to the scale-up, spread, and sustainability of health and care technologies,” Journal of medical Internet research, vol. 19, no. 11, p. e367, 2017. [Online]. Available: https://www.jmir.org/2017/11/e367/.

[128]    A. D. Knight, T. Lowe, M. Brossard, and J. Wilson. “A Whole New World: Funding and Commissioning in Complexity.” Human Learning Systems. https://collaboratecic.com/a-whole-new-world-funding-and-commissioning-in-complexity-12b6bdc2abd8 (accessed.

[129]    T. Foley. “Nonadoption, Abandonment, Scale-up, Spread and Sustainability in LHS Workshop.” The Learning Healthcare Project. www.learninghealthcareproject.org (accessed.

[130]    L. Hurst et al., “Defining Value-based Healthcare in the NHS,” 2019. [Online]. Available: http://www.cebm.net/wp-content/uploads/2019/04/Defining-Value-based-healthcare-in-the-NHS-Final4-1.pdf.

[131]    Parliament UK. “The role of the Department for Digital, Culture, Media and Sport.” Parliament UK. https://publications.parliament.uk/pa/cm5801/cmselect/cmcumeds/291/29108.htm (accessed.

[132]    T. Greenhalgh et al., “The NASSS-CAT Tools for Understanding, Guiding, Monitoring, and Researching Technology Implementation Projects in Health and Social Care: Protocol for an Evaluation Study in Real-World Settings,” JMIR research protocols, vol. 9, no. 5, p. e16861, 2020. [Online]. Available: https://www.researchprotocols.org/2020/5/e16861/.

[133]    H. J. Lanham, L. K. Leykum, B. S. Taylor, C. J. McCannon, C. Lindberg, and R. T. Lester, “How complexity science can inform scale-up and spread in health care: understanding the role of self-organization in variation across local contexts,” Social Science & Medicine, vol. 93, pp. 194-202, 2013. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/22819737/.

[134]    T. Greenhalgh and C. Papoutsi, “Spreading and scaling up innovation and improvement,” Bmj 365, p. 365, 2019. [Online]. Available: https://www.bmj.com/content/bmj/365/bmj.l2068.full.pdf.

[135]    L. Freedman, Strategy: A history. Oxford University Press, 2015.

[136]    H. Mintzberg, “Patterns in Strategy Formation,” International Studies of Management & Organization, vol. 9, no. 3, pp. 67-86, 1979. [Online]. Available: https://www.tandfonline.com/doi/abs/10.1080/00208825.1979.11656272.

[137]    J. Stewart, “The meaning of strategy in the public sector,” Australian Journal of Public Administration, vol. 63, no. 4, pp. 16-21, 2004. [Online]. Available: https://onlinelibrary.wiley.com/doi/10.1111/j.1467-8500.2004.00409.x.

[138]    A. G. Lafley and R. L. Martin, Playing to Win: How Strategy Really Works. Harvard Business Press, 2013.

[139]    HNHS Providers. “Building A Digital Strategy.” https://nhsproviders.org/building-a-digital-strategy (accessed.

[140]    M. E. Porter, “What Is Strategy?,” Harvard Business Review, vol. 74, no. 6, pp. 61-78, 1996. [Online]. Available: https://hbr.org/1996/11/what-is-strategy.

[141]    R. P. Rumelt, “Good strategy/bad strategy: The difference and why it matters,” Emerald insight, vol. 28, no. 8, 2012. [Online]. Available: https://www.emerald.com/insight/content/doi/10.1108/sd.2012.05628haa.002/full/html.

[142]    R. K. Sondhi, Total Strategy. BMC Global Services Publications, 2008.

[143]    StrategicCoffee. “How to design a Target Operating Model (TOM).” StrategicCoffee. https://strategiccoffee.chriscfox.com/2012/12/how-to-design-target-operating-model-tom.html (accessed.

[144]    D. Snowden and R. Greenberg, Cynefin – Weaving Sense-Making into the Fabric of Our World. Cognitive Edge, 2020.

[145]    M. T. Britto et al., “Using a network organisational architecture to support the development of Learning Healthcare Systems,” BMJ quality & safety, vol. 27, no. 11, pp. 937-946, 2018. [Online]. Available: https://qualitysafety.bmj.com/content/27/11/937.abstract.

[146]    S. Scobie and S. Castle-Clarke. “What can the NHS learn from learning health systems?” Nuffieldtrust. https://www.nuffieldtrust.org.uk/files/2019-05/learning-health-systems-v3.pdf (accessed.

[147]    R. Mannion and H. Davies, “Understanding organisational culture for healthcare quality improvement,” The BMJ, vol. 363, p. k4907, 2018. [Online]. Available: https://www.bmj.com/content/363/bmj.k4907.

[148]    T. Jung et al., “Instruments for Exploring Organizational Culture: A Review of the Literature,” Public Administration Review, vol. 69, no. 6, pp. 1087-1096, 2009. [Online]. Available: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1540-6210.2009.02066.x.

[149]    B. Shirai. “Dave Snowden — How leaders change culture though small actions.” Medium. https://medium.com/@brixen/dave-snowden-how-leaders-change-culture-though-small-actions-766cd2bf5128 (accessed.

[150]    The King’s Fund. “Improving NHS culture.” The King’s Fund. https://www.kingsfund.org.uk/projects/culture (accessed.

[151]    R. M. Wachter. “Making IT Work: Harnessing the Power of Health Information Technology to Improve Care in England.” GOV.UK. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/550866/Wachter_Review_Accessible.pdf (accessed 2021).

[152]    T. Foley and J. Woollard, “The digital future of mental healthcare and its workforce,” NHS UK, 2019. [Online]. Available: https://topol.hee.nhs.uk/downloads/digital-future-of-mental-healthcare-report/

[153]    T. Foley and F. Fairmichael. “Workforce and Training Focus Group.” The Learning Healthcare Project. http://www.learninghealthcareproject.org/section/evidence/12/71/training-and-workforce-focus-group (accessed.

[154]    Faculty of Clinical Informatics. “Core Competency Framework for Clinical Informaticians.” The Faculty of Clinical Informatics. https://facultyofclinicalinformatics.org.uk/core-competency-framework (accessed.

[155]    J. L. Magnabosco, “Innovations in mental health services implementation: A report on state-level data from the US evidence-based practices project,” Implementation Science, vol. 1, no. 1, p. 13, 2006. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562440/.

[156]    M. S. Bauer, L. Damschroder, H. Hagedorn, J. Smith, and A. M. Kilbourne, “An introduction to implementation science for the non-specialist,” BMC psychology, vol. 3, no. 1, p. 32, 2015. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573926/.

[157]    N. Page, M. T. Baysari, and J. I. Westbrook, “A systematic review of the effectiveness of interruptive medication prescribing alerts in hospital CPOE systems to change prescriber behavior and improve patient safety,” International journal of medical informatics, vol. 105, pp. 22-30, 2017. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/28750908/.

[158]    M. P. Eccles and B. S. Mittman, “Welcome to implementation science,” implementation science, 2006. [Online]. Available: https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-1-1.

[159]    S. Michie, M. M. V. Stralen, and R. West, “The behaviour change wheel: A new method for characterising and designing behaviour change interventions,” Implementation Science, vol. 6, no. 1, p. 42, 2011. [Online]. Available: https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-6-42.

[160]    K. E. Curtis, S. Lahir, and K. E. Brown, “Targeting Parents for Childhood Weight Management: Development of a Theory-Driven and User-Centered Healthy Eating App,” JMIR Mhealth Uhealth, 2015. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526951/.

[161]    T. Väänänen. “Design is the strategy.” NHS Digital. https://digital.nhs.uk/blog/design-matters/2020/design-is-the-strategy (accessed.

[162]    ISO. “Human-centred design for interactive systems.” ISO/TC 159/SC 4 Ergonomics of human-system interaction. https://www.iso.org/standard/77520.html (accessed.

[163]    NHS Digital. “Design principles.” NHS Digital. https://service-manual.nhs.uk/assets/nhs-design-principles.pdf (accessed.

[164]    S. Reponen. “Co-design Framework.” http://results.learning-layers.eu/ (accessed.

[165]    E. B.-N. Sanders and T. B. Eva Brandt, “A Framework for Organizing the Tools and Techniques of Participatory Design,” in Proceedings of the 11th biennial participatory design conference, 2010, pp. 195-198. [Online]. Available: https://dl.acm.org/doi/10.1145/1900441.1900476. [Online]. Available: https://dl.acm.org/doi/10.1145/1900441.1900476

[166]    M. Batalden et al., “Coproduction of healthcare service,” BMJ Quality and Safety, vol. 25, no. 7, 2015. [Online]. Available: https://qualitysafety.bmj.com/content/qhc/25/7/509.full.pdf.

[167]    P. Vandekerckhove, “Generative Participatory Design Methodology to Develop Electronic Health Interventions: Systematic Literature Review,” JMIR Publications, vol. 22, no. 4, 2020. [Online]. Available: https://www.jmir.org/2020/4/e13780/.

[168]    R. F. Dam and T. Y. Siang. “5 Stages in the Design Thinking Process.” Interaction Design Foundation. https://www.interaction-design.org/literature/article/5-stages-in-the-design-thinking-process (accessed.

[169]    C. Illuk. “The 2 hour Design Sprint.” https://blog.prototypr.io/the-2-hour-design-sprint-9e2bbc14ee1 (accessed.

[170]    Google. “Design Sprints.” Google. https://designsprintkit.withgoogle.com/ (accessed.

[171]    J. Knapp, J. Zeratsky, and B. Kowitz, Sprint: How to Solve Big Problems and Test New Ideas in Just Five Days. Simon and Schuster, 2016.

[172]    Service Design Tools. “Service Design Tools.” https://servicedesigntools.org/ (accessed.

[173]    Design Kit. “Design Kit.” https://www.designkit.org/ (accessed.

[174]    The Right Question. “The Right Question.” https://rightquestion.org/ (accessed.

[175]    P. o. C. Foundation. “EBCD: Experience-based co-design toolkit.” The Point of Care Foundation. https://www.pointofcarefoundation.org.uk/resource/experience-based-co-design-ebcd-toolkit/ (accessed.

[176]    Digital Health. “Co-design in Health.” Good Things Foundation: Digital Health Lab. https://digital-health-lab.org/codesign-in-health (accessed.

[177]    T. Foley. “Evaluation in LHS Workshop.” www.learninghealthcareproject.org (accessed.

[178]    NHS. “Future NHS.” NHS. https://future.nhs.uk/system/login?nextURL=%2Fconnect%2Eti%2Fhome%2Fgrouphome (accessed 2021).

[179]    J. Leviss, HIT Or Miss, 3rd Edition Lessons Learned from Health Information Technology Projects. Taylor & Francis, 2019.

[180]    P. Craig, P. Dieppe, S. Macintyre, S. Michie, I. Nazareth, and M. Petticrew, “Developing and evaluating complex interventions: the new Medical Research Council guidance,” BMJ, 2008. [Online]. Available: https://mrc.ukri.org/documents/pdf/complex-interventions-guidance/

[181]    C. Lannon et al., “A maturity grid assessment tool for learning networks,” Learning Health Systems, 2020. [Online]. Available: https://onlinelibrary.wiley.com/doi/full/10.1002/lrh2.10232.

[182]    HIMSS Analysis. “Adoption Model for Analytics Maturity.” HIMSS Analysis. https://www.himssanalytics.org/healthcare-provider-models/all (accessed.

[183]    C. J. Lindsell et al., “Learning From What We Do, and Doing What We Learn: A Learning Health Care System in Action,” Academic Medicine: Journal of the Association of American Medical Colleges, 2021. [Online]. Available: https://journals.lww.com/academicmedicine/Abstract/9000/Learning_From_What_We_Do,_and_Doing_What_We_Learn_.96789.aspx.

[184]    NHS. “NHS Knowledge Mobilisation Framework  ” https://www.e-lfh.org.uk/programmes/knowledge-mobilisation-framework/ (accessed 2021).

[185]    NHS Health EdEng. “Library and Knowledge Services in England.” NHS Health Education England. https://www.hee.nhs.uk/sites/default/files/HEE%20-%20Library%20and%20Knowledge%20Services%20Value%20Proposition%20The%20Gift%20of%20Time%20FINAL%20Nov2020_0.pdf (accessed 2021).

[186]    NICE. “Developing NICE guidelines: the manual Process and methods.” The National Institute for Health and Care Excellence (NICE). https://www.nice.org.uk/process/pmg20/chapter/decision-making-committees (accessed.

[187]    M. H. Murad, N. Asi, M. Alsawas, and F. Alahdab, “New evidence pyramid,” BMJ Evidence-based Medicine, vol. 21, no. 4, pp. 125-127, 2016. [Online]. Available: https://ebm.bmj.com/content/21/4/125.

[188]    A. Mitchell, “A NICE perspective on computable biomedical knowledge,” BMJ Health & Care Informatics, vol. 27, no. 2, 2020. [Online]. Available: https://informatics.bmj.com/content/27/2/e100126.

[189]    Faculty of Clinical Informatics. “Andrew Mitchell – UK Workshop on Mobilising Computable Biomedical Knowledge (MCBK).” Mobilizing Computable Biomedical Knowledge (MCBK). https://www.youtube.com/watch?v=lIHJLRjUjRo&list=PLn7CfTWFFBSzTZtK4bTpo7Q2kBLjr0RUM&index=8&t=135s (accessed.

[190]    AHRQ. “Improving quality of care through clinical decision support (CDS) takes a community.” Agency for Healthcare Research and Quality. https://cds.ahrq.gov/cdsconnect/about (accessed.

[191]    S. Jain. “How to Make Healthcare Innovation Work in the Real World—Merck’s Partnership with PatientsLikeMe.” Medical Marketing and Media. https://www.mmm-online.com/home/channel/suppliers/how-to-make-healthcare-innovation-work-in-the-real-world-mercks-partnership-with-patientslikeme/ (accessed.

[192]    J. Hibbard and H. Gilburt, “Supporting people to manage their health.” An introduction to patient activation,” The King’s Fund, London, UK, 2014. [Online]. Available: https://www.kingsfund.org.uk/sites/default/files/field/field_publication_file/supporting-people-manage-health-patient-activation-may14.pdf

[193]    T. Greenhalgh. “Assessing and handling complexity in technology projects.” https://www.researchprotocols.org/api/download?filename=e47188522869f9601723b92bbe0f7b18.docx&alt_name=16861-319949-1-SP.docx (accessed.

[194]    T. Greenhalgh. “NASSS-CAT (Project Version).” https://www.researchprotocols.org/api/download?filename=15d56b11e2f52e9308f7e0a15afb5222.docx&alt_name=16861-319950-1-SP.docx (accessed.

[195]    T. Greenhalgh. “Identifying complexities in your technology project.” https://www.researchprotocols.org/api/download?filename=21c2d1bfd3c40e2666e592da19e5bc8d.docx&alt_name=16861-319948-1-SP.docx (accessed.

[196]    D. Neuman, “Qualitative Research in Educational Communications and Technology: A brief introduction to Principles and Procedures,” Journal of Computing in Higher Education pp. 69-86, 2014.

[197]    IHI. “Introduction to Learning Health Networks.” IHI. https://ihi.webex.com/recordingservice/sites/ihi/recording/c1f65d0feafe4361a373e3feab417155/playback (accessed.

[198]    Institute of Healthcare Improvement. “About IHI.” Institute of Healthcare Improvement. http://www.ihi.org (accessed.

[199]    N. H. S. Alliance. “Connected Cities.” Nothern Health Science Alliance. https://www.connectedhealthcities.org/ (accessed.

[200]    NHS, “Joining up health and care data,” 2021. [Online]. Available: https://www.england.nhs.uk/digitaltechnology/connecteddigitalsystems/health-and-care-data/joining-up-health-and-care-data/.