By Lewis, G. H. Abstract Context: Predictive models can be used to identify people at high risk of unplanned hospitalization, although some of the high-risk…
By Institure of Medicine. Abstract The United States has the highest per capita spending on health care of any industrialized nation. Yet despite the unprecedented…
By Bradley, E. H., et al. BackgroundDespite decades of efforts to improve quality of health care, poor performance persists in many aspects of care. Less…
By Tannen Richard L, Weiner Mark G, Xie Dawei. Abstract Objectives To determine whether observational studies that use an electronic medical record database can provide…
By Miller, F. G. Abstract Observational research involving access to personally identifiable data in medical records has often been conducted without informed consent, owing to…
By Sanson-Fisher, R. W., et al. Abstract Population- and systems-based interventions need evaluation, but the randomized controlled trial (RCT) research design has significant limitations when…
By Lynn M. Etheredge. Abstract Private- and public-sector initiatives, using electronic health record (EHR) databases from millions of people, could rapidly advance the U.S. evidence…
By Johnston, S. C., et al. Abstract BACKGROUND: Few attempts have been made to estimate the public return on investment in medical research. The total…
By Kawamoto, K., et al. Abstract Objective To identify features of clinical decision support systems critical for improving clinical practice. Design Systematic review of randomised…
By Rothwell, P. M. Abstract In making treatment decisions, doctors and patients must take into account relevant randomised controlled trials (RCTs) and systematic reviews. Relevance…
By Matzen P. INTRODUCTION: In the early 1990es, it was supposed that only 10-15 per cent of medical interventions were based on results from randomised…
By Mann, C. J. Abstract Cohort, cross sectional, and case-control studies are collectively referred to as observational studies. Often these studies are the only practicable…
By Helms, P. J. Abstract Although the explanatory clinical therapeutic trial remains the foundation for assessing drug efficacy and is required for licensing purposes, the…
By Sibbald, B. and M. Roland. Abstract Randomised controlled trials are the most rigorous way of determining whether a cause-effect relation exists between treatment and…
By Black, N. Abstract The view is widely held that experimental methods (randomised controlled trials) are the “gold standard” for evaluation and that observational methods…
By Sackett, et al. Abstract It's about integrating individual clinical expertise and the best external evidence Evidence based medicine, whose philosophical origins extend back to…
By Davidoff, Frank et al. Abstract A new journal to help doctors identify the information they need Busy doctors have never had time to read…